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CS-W001157 4
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1-Methyl-1H-pyrazol-3-amine

  • CAS No. 1904-31-0

  • Cat. No. CS-M0755
  • Purity≥98%
  • MDL No.MFCD00466340

*For research and further manufacturing use only, not for direct human use.

1-Methyl-1H-pyrazol-3-amine|CS-M0755

Structure of 1904-31-0

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General Information

  • CAS No. 1904-31-0
  • Cat. No. CS-M0755
  • Purity ≥98%
  • MDL No. MFCD00466340
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₇N₃
  • Molecular Weight None
  • Synonym(s) None
  • SMILES NC1=NN(C)C=C1

Description

1-Methyl-1H-pyrazol-3-amine delivers a pyrazole scaffold with enhanced solubility and stability, featuring a methyl group at the N1 position that modulates electronic properties. This nitrogen-rich heterocycle integrates readily into bioactive molecules, serving as a key building block in medicinal chemistry for targeted ligand design.

Application

1-Methyl-1H-pyrazol-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyrazole scaffolds. Its primary amine functionality facilitates nucleophilic substitution and coupling reactions, while the methyl group enhances metabolic stability and modulates solubility. The compound exhibits good bench stability and is compatible with standard reaction conditions, making it well-suited for parallel synthesis and API intermediate development.

Synthesis

  • Route1
    • 4-iodo-1-methyl-3-nitro-1h-pyraZole|CS-0241416
      75092-34-1
    • ~51%
    • In-stock
      1-Methyl-1H-pyrazol-3-amine|CS-M0755
      1904-31-0

    References

    • Tret'yakov; Vasilevsky Russian Chemical Bulletin, 1996 , vol. 45, # 11 p. 2585 - 2587
  • Route2
    • In-stock
      1-methyl-3-nitropyrazole|CS-0061746
      54210-32-1
    • ~0%
    • null|null
      132038-69-8
    • In-stock
      1-Methyl-1H-pyrazol-3-amine|CS-M0755
      1904-31-0

    References

    • Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 26, # 8 p. 955
  • Route3
    • null|null
      91027-92-8
    • ~15%
    • 2,4-Dimethyl-2h,6h,7h-pyrazolo[3,4-b]pyridin-6-one|CS-0241185
      73810-75-0
    • In-stock
      1-Methyl-1H-pyrazol-3-amine|CS-M0755
      1904-31-0

    References

    • Polish Journal of Chemistry, , vol. 56, # 10-12 p. 1273 - 1278

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   0.0023
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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