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CS-W001157 4
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1-Ethyl-1H-pyrazol-5-amine

  • CAS No. 3528-58-3

  • Cat. No. CS-W011272
  • Molecule weight111.15
  • Purity≥98%
  • MDL No.MFCD00010849

*For research and further manufacturing use only, not for direct human use.

1-Ethyl-1H-pyrazol-5-amine|CS-W011272

Structure of 3528-58-3

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General Information

  • CAS No. 3528-58-3
  • Cat. No. CS-W011272
  • Purity ≥98%
  • MDL No. MFCD00010849
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉N₃
  • Molecular Weight 111.15
  • Synonym(s) 5-AMINO-1-ETHYLPYRAZOLE
  • SMILES CCN1N=CC=C1N

Description

1-Ethyl-1H-pyrazol-5-amine features a pyrazole core functionalized with an ethyl group at the 1-position and a primary amine at the 5-position. This configuration enables direct incorporation into heterocyclic scaffolds, offering enhanced solubility and stability in synthetic transformations. The pendant amine facilitates conjugation and further derivatization, making it a valuable intermediate for medicinal chemistry and materials science applications.

Application

1-Ethyl-1H-pyrazol-5-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrazole-based heterocycles through standard coupling and functionalization protocols. Its amine functionality facilitates direct derivatization, while the ethyl group enhances solubility and metabolic stability. The compound exhibits good bench stability and is compatible with common protecting group strategies, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
    • 1-Ethyl-5-nitro-1h-pyrazole|CS-0298251
      58793-47-8
    • ~%
    • In-stock
      1-Ethyl-1H-pyrazol-5-amine|CS-W011272
      3528-58-3

    References

    • WO2005/80359 A1, ; Page/Page column 91 ; WO 2005/080359 A1
  • Route2
    • null|null
      75-07-0
    • null|null
      107-13-1
    • ~15%
    • In-stock
      1-Ethyl-1H-pyrazol-5-amine|CS-W011272
      3528-58-3

    References

    • RANBAXY LABORATORIES LIMITED; RUDRA, Sonali; GUPTA, Nidhi; CHANDRAKANT, Kakade, Ganesh; JAIN, Tarun; VOLETI, Sreedhara, Rao; RAY, Abhijit; DASTIDAR, Sunanda G.; VIJAYKRISHNAN, Lalitha Patent: WO2010/46791 A1, 2010 ; Location in patent: Page/Page column 30-31 ; WO 2010/046791 A1
  • Route3
    • null|null
      42066-48-8
    • ~%
    • In-stock
      1-Ethyl-1H-pyrazol-5-amine|CS-W011272
      3528-58-3

    References

    • WO2008/9735 A1, ; Page/Page column 110 ; WO 2008/009735 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   0.4852
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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