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CS-W001157 4
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2-Propan-2-ylpyrazol-3-amine

  • CAS No. 3524-16-1

  • Cat. No. CS-0061038
  • Molecule weight125.17
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Propan-2-ylpyrazol-3-amine|CS-0061038

Structure of 3524-16-1

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General Information

  • CAS No. 3524-16-1
  • Cat. No. CS-0061038
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁N₃
  • Molecular Weight 125.17
  • Synonym(s) 2-Isopropyl-2H-pyrazol-3-ylamine
  • SMILES CC(C)N1C(=CC=N1)N

Application

1-(Propan-2-yl)-1H-pyrazol-5-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of pyrazole-based scaffolds through standard coupling and functionalization reactions. Its tertiary butyl-like isopropyl group enhances metabolic stability and lipophilicity, while the primary amine facilitates derivatization via acylation, alkylation, or transition-metal-catalyzed cross-coupling. The compound exhibits good bench stability and ease of purification, making it well-suited for high-throughput screening and process development workflows.

Synthesis

  • Route1
    • Isopropylhydrazine dihydrochloride|CS-0580294
      70629-60-6
    • null|null
      920-37-6
    • ~%
    • In-stock
      1-(Propan-2-yl)-1H-pyrazol-3-amine|CS-0052807
      857267-04-0
    • In-stock
      2-Propan-2-ylpyrazol-3-amine|CS-0061038
      3524-16-1

    References

    • WO2005/60970 A1, ; Page/Page column 161 ; WO 2005/060970 A1
  • Route2

    References

    • Ohki, Hidenori; Kawabata, Kohji; Inamoto, Yoshiko; Okuda, Shinya; Kamimura, Toshiaki; Sakane, Kazuo Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 8 p. 1685 - 1694
  • Route3
    • ethyl 5-amino-1-isopropyl-1H-pyrazole-4-carboxylate|CS-W000079
      1759-24-6
    • ~%
    • In-stock
      2-Propan-2-ylpyrazol-3-amine|CS-0061038
      3524-16-1

    References

    • Bioorganic and Medicinal Chemistry, , vol. 5, # 8 p. 1685 - 1694

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   1.0462
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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