Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

N1-Methyl-4-(trifluoromethyl)benzene-1,2-diamine

  • CAS No. 35203-49-7

  • Cat. No. CS-0046909
  • Purity≥97%
  • MDL No.MFCD01571385

*For research and further manufacturing use only, not for direct human use.

N1-Methyl-4-(trifluoromethyl)benzene-1,2-diamine|CS-0046909

Structure of 35203-49-7

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 35203-49-7
  • Cat. No. CS-0046909
  • Purity ≥97%
  • MDL No. MFCD01571385
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉F₃N₂
  • Molecular Weight None
  • Synonym(s) 2-methylamino-5-trifluoromethylaniline
  • SMILES FC(F)(C1=CC=C(NC)C(N)=C1)F

Description

N1-Methyl-4-(trifluoromethyl)benzene-1,2-diamine features a trifluoromethyl group that imparts enhanced electron-withdrawing character and metabolic stability. The methylated amine nitrogen improves solubility and reduces basicity compared to the parent diamine. This compound serves as a key building block for functionalized aromatic scaffolds in medicinal chemistry and materials science.

Application

N1-Methyl-4-(trifluoromethyl)benzene-1,2-diamine serves as a versatile building block in medicinal chemistry, enabling the synthesis of functionalized heterocycles and bioactive scaffolds. Its ortho-diamine motif facilitates cyclization reactions with carbonyl electrophiles, while the trifluoromethyl group enhances metabolic stability and lipophilicity. The N-methyl substitution improves solubility and reduces basicity, offering favorable handling and purification characteristics. This compound functions effectively in standard coupling and condensation protocols for API intermediate development.

Synthesis

  • Route1

    References

    • Bianchi; Butti; Rossi; et al. European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 321 - 326
  • Route2

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 6 p. 1455 - 1459
  • Route3
    • null|null
      300698-92-4
    • ~%
    • In-stock
      N1-Methyl-4-(trifluoromethyl)benzene-1,2-diamine|CS-0046909
      35203-49-7

    References

    • European Journal of Medicinal Chemistry, , vol. 41, # 1 p. 135 - 141

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   38.05
  • LogP   2.3293
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 35203-49-7 sigma35203-49-7 manufacturer35203-49-7 price35203-49-7 structure35203-49-7 SDSbuy 35203-49-735203-49-7 supplier35203-49-7 uses35203-49-7 molecular weightprice of 35203-49-735203-49-7 chemical name formula of 35203-49-7
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label