tert-Butyl (2R,4S)-4-amino-2-methylpyrrolidine-1-carboxylate

Name: tert-Butyl (2R,4S)-4-amino-2-methylpyrrolidine-1-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 348165-60-6
Cat. No. CS-0048631
Molecule weight200.28
Purity≥98%
MDL No.None

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tert-Butyl (2R,4S)-4-amino-2-methylpyrrolidine-1-carboxylate|CS-0048631

Structure of 348165-60-6

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General Information

CAS No. 348165-60-6
Cat. No. CS-0048631
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₂₀N₂O₂
Molecular Weight 200.28
Synonym(s) 2-Methyl-2-propanyl (2R,4S)-4-amino-2-methyl-1-pyrrolidinecarboxylate
SMILES C[C@@H]1C[C@H](N)CN1C(=O)OC(C)(C)C

Description

tert-Butyl (2R,4S)-4-amino-2-methylpyrrolidine-1-carboxylate is a chiral pyrrolidine derivative featuring a bench-stable tert-butyl carbamate protecting group and stereodefined amino and methyl functionalities. This configuration enables direct incorporation into complex peptide architectures and bioactive heterocycles, particularly in the synthesis of constrained peptidomimetics and kinase inhibitors.

Application

tert-Butyl (2R,4S)-4-amino-2-methylpyrrolidine-1-carboxylate serves as a stereochemically defined building block for the synthesis of bioactive heterocycles and peptidomimetics. The protected amine and chiral pyrrolidine core enable selective functionalization and compatibility with standard coupling reactions. Its bench-stable tert-butyl carbamate group facilitates straightforward deprotection and purification, making it ideal for iterative synthesis in medicinal chemistry workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 55.56
LogP 1.343
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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tert-Butyl (2R,4S)-4-amino-2-methylpyrrolidine-1-carboxylate

CAS No. 348165-60-6

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