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CS-W001157 4
Total: USD 88.00

4-(Hydroxymethyl)benzaldehyde

  • CAS No. 52010-97-6

  • Cat. No. CS-W005041
  • Purity≥97%
  • MDL No.MFCD11870191

*For research and further manufacturing use only, not for direct human use.

4-(Hydroxymethyl)benzaldehyde|CS-W005041

Structure of 52010-97-6

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General Information

  • CAS No. 52010-97-6
  • Cat. No. CS-W005041
  • Purity ≥97%
  • MDL No. MFCD11870191
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈O₂
  • Molecular Weight 136.15
  • Synonym(s) p-Tolualdehyde,a-hydroxy- (6CI,7CI)
  • SMILES OCC1=CC=C(C=O)C=C1

Description

4-(Hydroxymethyl)benzaldehyde features a benzaldehyde core with a pendant hydroxymethyl group at the para position, enabling dual functionality in synthetic transformations. This bifunctional scaffold integrates readily into polymer backbones and bioconjugation strategies, offering enhanced solubility and reactivity under standard conditions.

Application

4-(Hydroxymethyl)benzaldehyde serves as a versatile bifunctional building block in synthetic organic chemistry, enabling efficient access to functionalized aromatic scaffolds. The aldehyde group facilitates nucleophilic addition and condensation reactions, while the pendant hydroxymethyl moiety offers sites for oxidation, protection, or derivatization. Its bench-stable nature and compatibility with common reaction conditions make it well-suited for applications in medicinal chemistry and heterocycle synthesis.

Synthesis

  • Route1

    References

    • Kumar, Prashant; Singh, Ashish Kumar; Sharma, Sanjeev; Pandey, Daya Shankar Journal of Organometallic Chemistry, 2009 , vol. 694, # 22 p. 3643 - 3652
  • Route2
    • (4-(Dimethoxymethyl)phenyl)methanol|CS-0199629
      183057-64-9
    • ~97%
    • In-stock
      4-(Hydroxymethyl)benzaldehyde|CS-W005041
      52010-97-6

    References

    • ASTRAZENECA AB Patent: WO2008/136756 A1, 2008 ; Location in patent: Page/Page column 126 ; WO 2008/136756 A1
  • Route3
    • null|null
      125734-44-3
    • ~98%
    • In-stock
      4-(Hydroxymethyl)benzaldehyde|CS-W005041
      52010-97-6

    References

    • LIGHTSHIP MEDICAL LIMITED; JAMES, Tony; BARWELL, Nicholas, Paul Patent: WO2012/95628 A1, 2012 ; Location in patent: Page/Page column 15-16 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   0.9914
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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