3-Amino-2-chloro-6-methoxypyridine

Name: 3-Amino-2-chloro-6-methoxypyridine
Brand: ChemScene
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CAS No. 34392-85-3
Cat. No. CS-W021831
Purity≥97%
MDL No.MFCD09258809

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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3-Amino-2-chloro-6-methoxypyridine|CS-W021831

Structure of 34392-85-3

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Description

3-Amino-2-chloro-6-methoxypyridine is a functionalized pyridine derivative featuring a strategically positioned amino group and methoxy substituent. This electron-rich scaffold enables direct incorporation into heterocyclic architectures, offering enhanced solubility and reactivity in cross-coupling and cyclization processes. The chloro group provides a reliable handle for nucleophilic substitution, facilitating rapid diversification in medicinal chemistry and materials synthesis workflows.

Application

3-Amino-2-chloro-6-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized pyridine scaffolds. The amino group facilitates nucleophilic substitution and coupling reactions, while the chloro and methoxy substituents offer orthogonal reactivity for late-stage diversification. Its bench-stable nature and compatibility with standard cross-coupling protocols make it well-suited for iterative synthesis of heterocyclic compounds and API intermediates.

General Information

CAS No. 34392-85-3
Cat. No. CS-W021831
Purity ≥97%
MDL No. MFCD09258809
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇ClN₂O
Molecular Weight 158.59
Synonym(s) 2-Chloro-6-methoxypyridin-3-amine
SMILES COC1=CC=C(N)C(Cl)=N1

Computational Chemistry Data

TPSA 48.14
LogP 1.3258
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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3-Amino-2-chloro-6-methoxypyridine

CAS No. 34392-85-3

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