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CS-W001157 4
Total: USD 88.00

5-Chloro-6-methoxypyridin-3-amine

  • CAS No. 158387-20-3

  • Cat. No. CS-W005421
  • Purity≥98%
  • MDL No.MFCD13190367

*For research and further manufacturing use only, not for direct human use.

5-Chloro-6-methoxypyridin-3-amine|CS-W005421

Structure of 158387-20-3

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General Information

  • CAS No. 158387-20-3
  • Cat. No. CS-W005421
  • Purity ≥98%
  • MDL No. MFCD13190367
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇ClN₂O
  • Molecular Weight 158.59
  • Synonym(s) None
  • SMILES NC1=CC(Cl)=C(OC)N=C1

Description

5-Chloro-6-methoxypyridin-3-amine integrates a chlorine substituent and a methoxy group on a pyridine scaffold, delivering enhanced electron-withdrawing character and improved solubility. This bench-stable heterocycle serves as a key building block in medicinal chemistry, enabling efficient coupling reactions for targeted synthesis of bioactive compounds.

Application

5-Chloro-6-methoxypyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based scaffolds. Its ortho-chloro and amine functionalities facilitate palladium-catalyzed cross-coupling reactions and nucleophilic substitutions, while the methoxy group offers moderate stability and tunable reactivity. The compound exhibits excellent bench stability and is readily purified by standard chromatographic methods, making it well-suited for scalable synthesis and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.3258
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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