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Structure of 18699-87-1
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2-Methyl-3-nitropyridine features a nitro group at the 3-position and a methyl substituent at the 2-position of the pyridine ring, creating a sterically hindered, electron-deficient heterocycle. This combination enhances stability and directs electrophilic substitution regioselectively, making it valuable for synthesizing advanced pharmaceutical intermediates and functionalized ligands in catalysis.
2-Methyl-3-nitropyridine serves as a versatile heterocyclic building block in medicinal chemistry and agrochemical synthesis. Its nitro group enables electrophilic substitution, while the methyl substituent provides a handle for directed metalation or oxidation to carboxylic acid derivatives. The compound exhibits bench stability, facilitates straightforward purification, and participates reliably in Pd-catalyzed cross-coupling reactions, making it well-suited for constructing complex nitrogen-containing scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: