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6-Chloro-2-methoxypyridin-3-amine

  • CAS No. 914222-86-9

  • Cat. No. CS-0054545
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Chloro-2-methoxypyridin-3-amine|CS-0054545

Structure of 914222-86-9

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General Information

  • CAS No. 914222-86-9
  • Cat. No. CS-0054545
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇ClN₂O
  • Molecular Weight 158.59
  • Synonym(s) 6-Chloro-2-methoxy-pyridin-3-ylamine
  • SMILES NC1=CC=C(Cl)N=C1OC

Description

6-Chloro-2-methoxypyridin-3-amine features a pyridine core functionalized with chlorine at the 6-position and a methoxy group at C2, enabling selective coupling in late-stage diversification. The amine moiety provides a reactive handle for conjugation, while the electron-withdrawing chlorine enhances regioselectivity in cross-coupling reactions. This scaffold delivers robust performance under standard conditions.

Application

6-Chloro-2-methoxypyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds through palladium-catalyzed cross-coupling reactions. The chloro group facilitates C–C and C–N bond formation under standard conditions, while the methoxy and amine functionalities offer orthogonal reactivity for downstream derivatization. Bench-stable and readily purified by column chromatography, it supports scalable synthesis of targeted heterocycles and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.3258
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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