3-Amino-4-hydroxypyridine

Name: 3-Amino-4-hydroxypyridine
Brand: ChemScene
Availability: InStock
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CAS No. 6320-39-4
Cat. No. CS-W008020
Purity≥97%
MDL No.MFCD04114230

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 6320-39-4

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General Information

CAS No. 6320-39-4
Cat. No. CS-W008020
Purity ≥97%
MDL No. MFCD04114230
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₆N₂O
Molecular Weight None
Synonym(s) 4-Pyridinol, 3-amino-
SMILES OC1=C(N)C=NC=C1

Description

3-Amino-4-hydroxypyridine is a bifunctional heterocyclic building block featuring an amino group and a hydroxyl moiety on adjacent ring positions. This arrangement enables dual reactivity in synthetic transformations, supporting efficient coupling strategies in medicinal chemistry. The molecule exhibits enhanced solubility in polar solvents and demonstrates stability under standard bench conditions, facilitating use in process development workflows.

Application

3-Amino-4-hydroxypyridine serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds via standard coupling and cyclization reactions. Its dual functionality—amine and hydroxyl groups—offers orthogonal reactivity for selective derivatization, while demonstrating robust bench stability and compatibility with common purification methods.

Synthesis

Route1
- In-stock
  
  5435-54-1
- ~99%
- In-stock
  
  6320-39-4
References
- Ahn, Sung Oh; Park, Chan Hee; Im, Jun Hwan; Lee, Soon Ok; Lee, Kyoung June; Cho, Seong Wook; Ko, Kwang Seok; Han, Sun Young; Lee, Won Il Patent: US2011/28467 A1, 2011 ; Location in patent: Page/Page column 15 ; US 20110028467 A1
Route2
- 101654-28-8
- ~%
- In-stock
  
  6320-39-4
References
- Yakugaku Zasshi, , vol. 76, p. 1388,1390, 1393 Chem.Abstr., , p. 6634

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 1759
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 59.14
LogP 0.3694
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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3-Amino-4-hydroxypyridine

CAS No. 6320-39-4

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