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5-Amino-2-chloropyridin-4-ol

  • CAS No. 138084-66-9

  • Cat. No. CS-0187095
  • Purity≥97%
  • MDL No.MFCD13189886

*For research and further manufacturing use only, not for direct human use.

5-Amino-2-chloropyridin-4-ol|CS-0187095

Structure of 138084-66-9

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General Information

  • CAS No. 138084-66-9
  • Cat. No. CS-0187095
  • Purity ≥97%
  • MDL No. MFCD13189886
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅ClN₂O
  • Molecular Weight None
  • Synonym(s) 5-aMino-2-chloropyridin-4-ol hydrochloride
  • SMILES C1=C(C(=CN=C1Cl)N)O

Description

5-Amino-2-chloropyridin-4-ol features a strategically positioned amino group and a chlorine atom on a pyridinol scaffold, enabling direct functionalization at the 4-position. This combination delivers enhanced reactivity in cross-coupling processes and facilitates integration into bioactive heterocycles. The molecule exhibits favorable solubility and stability under standard bench conditions.

Application

5-Amino-2-chloropyridin-4-ol serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles. Its ortho-halogenated pyridinol scaffold facilitates palladium-catalyzed cross-coupling reactions and provides a platform for site-specific derivatization. The amino and hydroxyl groups offer complementary handles for selective functionalization, while the molecule exhibits sufficient bench stability for routine handling and purification.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   59.14
  • LogP   1.0228
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   0

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