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CS-W001157 4
Total: USD 88.00

2,4-Dichloro-3-iodopyridine

  • CAS No. 343781-36-2

  • Cat. No. CS-W012338
  • Purity≥98%
  • MDL No.MFCD09033756

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloro-3-iodopyridine|CS-W012338

Structure of 343781-36-2

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General Information

  • CAS No. 343781-36-2
  • Cat. No. CS-W012338
  • Purity ≥98%
  • MDL No. MFCD09033756
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂Cl₂IN
  • Molecular Weight 273.88
  • Synonym(s) 2,4-dichloro-3-iodopy-ridine
  • SMILES IC1=C(Cl)C=CN=C1Cl

Description

2,4-Dichloro-3-iodopyridine offers a strategically positioned iodine atom on a chlorinated pyridine scaffold, enabling direct coupling in cross-coupling reactions. The electron-deficient heterocycle facilitates palladium-catalyzed transformations, while the orthogonal halogen pattern supports sequential functionalization. This bench-stable reagent integrates efficiently into complex molecule synthesis workflows.

Application

2,4-Dichloro-3-iodopyridine serves as a versatile building block in cross-coupling chemistry, enabling efficient access to substituted pyridines via palladium-catalyzed reactions. The iodo group facilitates Suzuki, Stille, and Negishi couplings, while the dichloro substituents offer orthogonal reactivity for further functionalization. Its bench-stable nature and compatibility with standard reaction conditions make it ideal for iterative synthesis of complex heterocyclic scaffolds in medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC; ADDEX PHARMA S.A.; CID-NUNEZ, Jose, Maria; DE LUCAS OLIVARES, Ana, Isabel; TRABANCO-SUAREZ, Andres, Avelino; MACDONALD, Gregor, James Patent: WO2010/130423 A1, 2010 ; Location in patent: Page/Page column 53 ; WO 2010/130423 A1
  • Route2
    • 4-Hydroxy-3-iodopyridin-2(1H)-one|CS-0569548
      1100932-71-5
    • ~%
    • In-stock
      2,4-Dichloro-3-iodopyridine|CS-W012338
      343781-36-2

    References

    • WO2011/32277 A1, ; Page/Page column 40-41 ; WO 2011/032277 A1
  • Route3

    References

    • WO2011/32277 A1, ; WO 2011/032277 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.993
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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