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CS-W001157 4
Total: USD 88.00

2,4-Dichloropyridine

  • CAS No. 26452-80-2

  • Cat. No. CS-W004774
  • Purity≥98%
  • MDL No.MFCD00955618

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloropyridine|CS-W004774

Structure of 26452-80-2

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General Information

  • CAS No. 26452-80-2
  • Cat. No. CS-W004774
  • Purity ≥98%
  • MDL No. MFCD00955618
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃Cl₂N
  • Molecular Weight None
  • Synonym(s) 2,4-Dichlorpyridin; 2,4-Dichloropyridine
  • SMILES C1=C(C=C(N=C1)Cl)Cl

Description

2,4-Dichloropyridine serves as a pivotal building block in medicinal chemistry and agrochemical synthesis. The molecule features two chlorine substituents at electron-deficient positions, enabling selective functionalization via palladium-catalyzed cross-coupling. This facilitates efficient access to complex heterocyclic architectures under mild conditions.

Application

2,4-Dichloropyridine serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of heterocyclic scaffolds through nucleophilic substitution. Its dual chloro substituents at electron-deficient positions facilitate regioselective functionalization under mild conditions. The compound exhibits excellent bench stability and compatibility with diverse reaction environments, making it ideal for medicinal chemistry campaigns and process-scale synthesis.

Synthesis

  • Route1
    • null|null
      1124-33-0
    • ~14%
    • In-stock
      2,4-Dichloropyridine|CS-W004774
      26452-80-2

    References

    • BIONOMICS LIMITED Patent: WO2008/70908 A1, 2008 ; Location in patent: Page/Page column 74 ;
  • Route2

    References

    • Marzi, Elena; Bigi, Anna; Schlosser, Manfred European Journal of Organic Chemistry, 2001 , # 7 p. 1371 - 1376
  • Route3
    • null|null
      837365-03-4
    • ~68%
    • In-stock
      2,4-Dichloropyridine|CS-W004774
      26452-80-2

    References

    • Schlosser, Manfred; Bobbio, Carla; Rausis, Thierry Journal of Organic Chemistry, 2005 , vol. 70, # 7 p. 2494 - 2502

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H317-H318
Precautionary Statements : P264-P270-P280-P301+P310-P302+P352-P305+P351+P338-P310-P330-P332+P313-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.3884
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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