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CS-W001157 4
Total: USD 88.00

2,4-Dichloro-5-iodopyridine

  • CAS No. 343781-49-7

  • Cat. No. CS-W021506
  • Purity≥98%
  • MDL No.MFCD09033755

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloro-5-iodopyridine|CS-W021506

Structure of 343781-49-7

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General Information

  • CAS No. 343781-49-7
  • Cat. No. CS-W021506
  • Purity ≥98%
  • MDL No. MFCD09033755
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂Cl₂IN
  • Molecular Weight None
  • Synonym(s) Pyridine, 2,4-dichloro-5-iodo-
  • SMILES IC1=CN=C(Cl)C=C1Cl

Description

2,4-Dichloro-5-iodopyridine is a halogenated pyridine derivative featuring complementary reactive sites for cross-coupling and functionalization. The electron-deficient ring facilitates palladium-catalyzed reactions, while the iodine moiety enables selective C–C bond formation. This compound serves as a key building block in medicinal chemistry and agrochemical synthesis, offering high reactivity under mild conditions.

Application

2,4-Dichloro-5-iodopyridine serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The iodine moiety facilitates efficient Suzuki, Stille, or Negishi couplings, while the dichloro substitution pattern allows for selective functionalization. Its bench-stable nature and compatibility with standard reaction conditions make it ideal for constructing complex pyridine-based scaffolds in API development and materials science applications.

Synthesis

  • Route1

    References

    • Marzi, Elena; Bigi, Anna; Schlosser, Manfred European Journal of Organic Chemistry, 2001 , # 7 p. 1371 - 1376
  • Route2
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      109-09-1
    • ~%
    • In-stock
      2,4-Dichloro-5-iodopyridine|CS-W021506
      343781-49-7

    References

    • European Journal of Organic Chemistry, , # 7 p. 1371 - 1376
  • Route3

    References

    • European Journal of Organic Chemistry, , # 7 p. 1371 - 1376

Safety Information

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.993
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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