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Structure of 3435-26-5
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4-Chloro-6-phenylpyrimidine features a fused pyrimidine core with a chlorine substituent at C4 and a phenyl group at C6, delivering enhanced electron-withdrawing character and structural rigidity. This configuration supports efficient coupling in cross-coupling reactions and facilitates integration into pharmaceutical scaffolds requiring planar, electron-deficient heterocycles under standard conditions.
4-Chloro-6-phenylpyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles via palladium-catalyzed cross-coupling reactions. Its well-established reactivity profile supports reliable functionalization at the C4 position, while the phenyl and pyrimidine moieties provide structural rigidity and favorable pharmacophoric properties for target-directed synthesis. The compound exhibits excellent bench stability and facilitates straightforward purification, making it ideal for scalable applications in API development and library generation.
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GHS Pictogram :
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GHS No : GHS05,GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H318
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Precautionary Statements : P264-P270-P330-P405-P501
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Lot numbers can be found on the outside label of a product: