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CS-W001157 4
Total: USD 88.00

4-Chloro-6-phenylpyrimidine

  • CAS No. 3435-26-5

  • Cat. No. CS-0045908
  • Purity≥97%
  • MDL No.MFCD00234604
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Chloro-6-phenylpyrimidine|CS-0045908

Structure of 3435-26-5

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Description

4-Chloro-6-phenylpyrimidine features a fused pyrimidine core with a chlorine substituent at C4 and a phenyl group at C6, delivering enhanced electron-withdrawing character and structural rigidity. This configuration supports efficient coupling in cross-coupling reactions and facilitates integration into pharmaceutical scaffolds requiring planar, electron-deficient heterocycles under standard conditions.

Application

4-Chloro-6-phenylpyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles via palladium-catalyzed cross-coupling reactions. Its well-established reactivity profile supports reliable functionalization at the C4 position, while the phenyl and pyrimidine moieties provide structural rigidity and favorable pharmacophoric properties for target-directed synthesis. The compound exhibits excellent bench stability and facilitates straightforward purification, making it ideal for scalable applications in API development and library generation.

General Information

  • CAS No. 3435-26-5
  • Cat. No. CS-0045908
  • Purity ≥97%
  • MDL No. MFCD00234604
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇ClN₂
  • Molecular Weight 190.63
  • Synonym(s) OTAVA-BB BB7020361158
  • SMILES ClC1=NC=NC(C2=CC=CC=C2)=C1

Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.797
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group :
Hazard Statements : H301-H318
Precautionary Statements : P264-P270-P330-P405-P501

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