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CS-W001157 4
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Methyl indoline-6-carboxylate

  • CAS No. 341988-36-1

  • Cat. No. CS-0019056
  • Purity≥95%
  • MDL No.MFCD07371629

*For research and further manufacturing use only, not for direct human use.

Methyl indoline-6-carboxylate|CS-0019056

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General Information

  • CAS No. 341988-36-1
  • Cat. No. CS-0019056
  • Purity ≥95%
  • MDL No. MFCD07371629
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁NO₂
  • Molecular Weight None
  • Synonym(s) Methyl indoline-6-carboxylate; methyl 2,3-dihydro-1H-indole-6-carboxylatato
  • SMILES O=C(C1=CC2=C(C=C1)CCN2)OC

Description

Methyl indoline-6-carboxylate is a bench-stable, electron-rich heterocyclic ester featuring a fused indoline core with a strategically positioned methyl carboxylate group. This scaffold integrates readily into synthetic sequences requiring nitrogen-containing aromatic systems, offering high compatibility in transition metal-catalyzed coupling reactions and serving as a key building block for bioactive molecule synthesis.

Application

Methyl indoline-6-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient construction of biologically relevant heterocyclic scaffolds. Its indoline core offers favorable functional group tolerance and stability under standard reaction conditions, while the ester moiety facilitates downstream transformations such as hydrolysis, reduction, or coupling reactions. This compound functions effectively in multistep synthesis workflows for API development and is well-suited for bench-scale applications due to its ease of handling and purification.

Synthesis

  • Route1

    References

    • Ackermann, Jean; Bleicher, Konrad; Ceccarelli Grenz, Simona M.; Chomienne, Odile; Mattei, Patrizio; Schulz-Gasch, Tanja Patent: US2007/60567 A1, 2007 ; Location in patent: Page/Page column 25 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   1.4412
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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