7-Chloro-1,6-naphthyridin-2(1H)-one

Name: 7-Chloro-1,6-naphthyridin-2(1H)-one
Brand: ChemScene
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CAS No. 1345091-18-0
Cat. No. CS-0201415
Purity≥96%
MDL No.MFCD22548048

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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7-Chloro-1,6-naphthyridin-2(1H)-one|CS-0201415

Structure of 1345091-18-0

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Description

7-Chloro-1,6-naphthyridin-2(1H)-one features a fused bicyclic core with a chlorinated position at C7 and a lactam functionality at N2, offering enhanced electron-withdrawing character. This scaffold integrates readily into pharmaceutical intermediates, enabling efficient access to kinase inhibitors and bioactive heterocycles under standard coupling conditions.

Application

7-Chloro-1,6-naphthyridin-2(1H)-one serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient construction of bioactive scaffolds. Its electrophilic C7-chlorine facilitates palladium-catalyzed cross-coupling reactions, while the 1,6-naphthyridin-2-one core offers hydrogen-bonding capacity and metabolic stability. The compound exhibits bench stability, moderate solubility, and compatibility with common protecting group strategies, making it well-suited for iterative synthesis and lead optimization workflows.

General Information

CAS No. 1345091-18-0
Cat. No. CS-0201415
Purity ≥96%
MDL No. MFCD22548048
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₅ClN₂O
Molecular Weight 180.59
Synonym(s) 7-chloro-1H-1,6-naphthyridin-2-one
SMILES O=C1NC2=C(C=NC(Cl)=C2)C=C1

Computational Chemistry Data

TPSA 45.75
LogP 1.5765
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Naphthyridine compounds

Key Words

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7-Chloro-1,6-naphthyridin-2(1H)-one

CAS No. 1345091-18-0

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