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CS-W001157 4
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3-Bromo-1-chloronaphthalene

  • CAS No. 325956-47-6

  • Cat. No. CS-0134842
  • Purity≥97%
  • MDL No.MFCD17012546

*For research and further manufacturing use only, not for direct human use.

3-Bromo-1-chloronaphthalene|CS-0134842

Structure of 325956-47-6

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General Information

  • CAS No. 325956-47-6
  • Cat. No. CS-0134842
  • Purity ≥97%
  • MDL No. MFCD17012546
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₆BrCl
  • Molecular Weight 241.51
  • Synonym(s) 3-bromo-1-chloro-naphthalene
  • SMILES ClC1=C2C=CC=CC2=CC(Br)=C1

Description

3-Bromo-1-chloronaphthalene is a halogenated naphthalene derivative featuring complementary reactivity at the 3-bromo and 1-chloro positions. This molecule integrates seamlessly into palladium-catalyzed cross-coupling reactions, enabling efficient synthesis of complex biaryl architectures under standard conditions. The electron-deficient aromatic core enhances regioselective functionalization, while the bench-stable nature simplifies handling in synthetic workflows.

Application

3-Bromo-1-chloronaphthalene serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The ortho-halogenated naphthalene core provides excellent functional group tolerance and bench stability, facilitating efficient construction of complex biaryl systems and heterocyclic scaffolds relevant to pharmaceutical and materials research.

Synthesis

  • Route1
    • 4-Methyl-N-(naphthalen-2-yl)benzenesulfonamide|CS-0333792
      18271-18-6
    • ~%
    • In-stock
      3-Bromo-1-chloronaphthalene|CS-0134842
      325956-47-6

    References

    • Bell Journal of the Chemical Society, 1953 , p. 3035,3037, 3040
  • Route2
    • null|null
      858841-74-4
    • ~%
    • In-stock
      3-Bromo-1-chloronaphthalene|CS-0134842
      325956-47-6

    References

    • Bell Journal of the Chemical Society, 1953 , p. 3035,3037, 3040
  • Route3
    • null|null
      93328-39-3
    • ~%
    • In-stock
      3-Bromo-1-chloronaphthalene|CS-0134842
      325956-47-6

    References

    • Bell Journal of the Chemical Society, 1953 , p. 3035,3037, 3040

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   4.2557
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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