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CS-W001157 4
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2-Bromo-6-chloronaphthalene

  • CAS No. 870822-84-7

  • Cat. No. CS-0141432
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Bromo-6-chloronaphthalene|CS-0141432

Structure of 870822-84-7

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General Information

  • CAS No. 870822-84-7
  • Cat. No. CS-0141432
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₆BrCl
  • Molecular Weight 241.51
  • Synonym(s) 2-Bromo-6-chloronaphthalen
  • SMILES ClC1=CC2=CC=C(Br)C=C2C=C1

Description

2-Bromo-6-chloronaphthalene is a halogenated naphthalene derivative featuring bromine at the 2-position and chlorine at the 6-position, enabling selective cross-coupling reactions. This electron-deficient scaffold integrates readily into complex molecular architectures, offering enhanced stability under standard conditions for synthetic applications in medicinal chemistry and materials science.

Application

2-Bromo-6-chloronaphthalene serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient access to substituted naphthalene scaffolds. Its orthogonal halogen reactivity facilitates sequential functionalization, while the bench-stable aryl halide core supports reliable operation in Pd-catalyzed couplings and C–H activation protocols.

Synthesis

  • Route1
    • null|null
      87700-60-5
    • ~%
    • In-stock
      2-Bromo-6-chloronaphthalene|CS-0141432
      870822-84-7

    References

    • Parmee, Emma R.; Xiong, Yusheng; Guo, Jian; Liang, Rui; Brockunier, Linda Patent: US2005/272794 A1, 2005 ; Location in patent: Page/Page column 21 ; US 20050272794 A1
  • Route2

    References

    • Woroshzow; Prshijalgowskaja Zhurnal Obshchei Khimii, 1954 , vol. 24, p. 1787,1789; engl. Ausg. S. 1755, 1756
  • Route3
    • null|null
      7647-01-0
    • In-stock
      1-Bromonaphthalene|CS-0017140
      90-11-9
    • ~%
    • In-stock
      2-Bromo-6-chloronaphthalene|CS-0141432
      870822-84-7

    References

    • Woroshzow; Prshijalgowskaja Zhurnal Obshchei Khimii, 1954 , vol. 24, p. 1787,1789; engl. Ausg. S. 1755, 1756

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   4.2557
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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