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CS-W001157 4
Total: USD 88.00

(4-Chloro-2-fluoro-5-formylphenyl)boronic acid

  • CAS No. 325786-27-4

  • Cat. No. CS-0162843
  • Molecule weight202.38
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(4-Chloro-2-fluoro-5-formylphenyl)boronic acid|CS-0162843

Structure of 325786-27-4

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General Information

  • CAS No. 325786-27-4
  • Cat. No. CS-0162843
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BClFO₃
  • Molecular Weight 202.38
  • Synonym(s) Boronic acid, (4-chloro-2-fluoro-5-formylphenyl)- (9CI)
  • SMILES O=CC1=C(Cl)C=C(F)C(B(O)O)=C1

Description

This boronic acid features a trifunctional aryl scaffold with chloro, fluoro, and formyl groups positioned ortho to the boronic acid moiety. The electron-deficient ring enhances reactivity in Suzuki-Miyaura coupling, while the formyl group enables downstream functionalization. Bench-stable under standard conditions, it facilitates efficient access to complex heterocycles and pharmaceutical intermediates.

Application

(4-Chloro-2-fluoro-5-formylphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling the construction of complex arylated scaffolds with high functional group tolerance. The formyl group provides additional site for downstream derivatization, while the boronic acid moiety offers excellent bench stability and ease of purification. This reagent facilitates efficient access to substituted heterocycles and biaryl architectures relevant to medicinal chemistry and materials science.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   -0.0286
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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