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CS-W001157 4
Total: USD 88.00

4-Chloro-3-formylphenylboronic acid

  • CAS No. 2354338-14-8

  • Cat. No. CS-0178452
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Chloro-3-formylphenylboronic acid|CS-0178452

Structure of 2354338-14-8

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General Information

  • CAS No. 2354338-14-8
  • Cat. No. CS-0178452
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BClO₃
  • Molecular Weight 184.38
  • Synonym(s) None
  • SMILES OB(C1=CC=C(Cl)C(C=O)=C1)O

Description

4-Chloro-3-formylphenylboronic acid features a boronic acid group paired with an ortho-formyl substituent on a chlorinated aromatic ring, enabling efficient coupling in Suzuki-Miyaura reactions. This configuration supports direct functionalization of complex heterocycles and facilitates the synthesis of biaryl scaffolds with enhanced electronic tunability.

Application

4-Chloro-3-formylphenylboronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling efficient C–C bond formation under mild conditions. The orthogonal reactivity of the aldehyde and boronic acid groups facilitates sequential functionalization, while its bench-stable nature simplifies handling and purification. This compound is particularly valuable for constructing complex aromatic scaffolds in medicinal chemistry and materials science.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   -0.1677
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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