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CS-W001157 4
Total: USD 88.00

2-Bromo-5-chloronicotinic acid

  • CAS No. 65550-79-0

  • Cat. No. CS-D0786
  • Purity≥97%
  • MDL No.MFCD09743884

*For research and further manufacturing use only, not for direct human use.

2-Bromo-5-chloronicotinic acid|CS-D0786

Structure of 65550-79-0

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General Information

  • CAS No. 65550-79-0
  • Cat. No. CS-D0786
  • Purity ≥97%
  • MDL No. MFCD09743884
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrClNO₂
  • Molecular Weight None
  • Synonym(s) tert-butyl 3-allyl-3-hydroxyazetidine-106-carboxylate
  • SMILES O=C(C1=CC(Cl)=CN=C1Br)O

Description

2-Bromo-5-chloronicotinic acid is a halogenated pyridine carboxylic acid featuring bromo and chloro substituents at the 2- and 5-positions, respectively. This electron-deficient heterocycle integrates readily into cross-coupling reactions, serving as a key building block for pharmaceutical intermediates and agrochemicals. The molecule exhibits enhanced stability under standard bench conditions and demonstrates favorable solubility in polar organic solvents.

Application

2-Bromo-5-chloronicotinic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-bromine and meta-chlorine substituents enable selective metal-catalyzed cross-coupling reactions, while the carboxylic acid group facilitates direct derivatization or salt formation. The compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for use in iterative synthetic sequences targeting complex nitrogen-containing scaffolds.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.1957
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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