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CS-W001157 4
Total: USD 88.00

2,4-Difluoro-3-iodopyridine

  • CAS No. 837364-88-2

  • Cat. No. CS-0005569
  • Purity≥98%
  • MDL No.MFCD09029861

*For research and further manufacturing use only, not for direct human use.

2,4-Difluoro-3-iodopyridine|CS-0005569

Structure of 837364-88-2

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General Information

  • CAS No. 837364-88-2
  • Cat. No. CS-0005569
  • Purity ≥98%
  • MDL No. MFCD09029861
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂F₂IN
  • Molecular Weight 240.98
  • Synonym(s) Pyridine, 2,4-difluoro-3-iodo-
  • SMILES IC1=C(F)C=CN=C1F

Description

2,4-Difluoro-3-iodopyridine serves as a pivotal building block in cross-coupling chemistry, featuring orthogonal reactivity due to its strategically positioned fluorine and iodine substituents. This electron-deficient pyridine enables selective palladium-catalyzed transformations, integrating seamlessly into complex molecular architectures under standard conditions.

Application

2,4-Difluoro-3-iodopyridine serves as a versatile building block in cross-coupling chemistry, enabling efficient palladium-catalyzed transformations due to its orthogonal halogen reactivity. The iodo group facilitates rapid coupling with boronic acids, while the difluoro substitution enhances electrophilicity and improves reaction kinetics. This compound offers excellent bench stability, ease of purification, and compatibility with diverse functional groups, making it ideal for constructing complex heterocyclic scaffolds in medicinal chemistry and agrochemical research.

Synthesis

  • Route1

    References

    • Schlosser, Manfred; Bobbio, Carla; Rausis, Thierry Journal of Organic Chemistry, 2005 , vol. 70, # 7 p. 2494 - 2502
  • Route2
    • null|null
      837364-97-3
    • ~90%
    • In-stock
      2,4-Difluoro-3-iodopyridine|CS-0005569
      837364-88-2

    References

    • Schlosser, Manfred; Bobbio, Carla; Rausis, Thierry Journal of Organic Chemistry, 2005 , vol. 70, # 7 p. 2494 - 2502
  • Route3
    • null|null
      837364-95-1
    • ~%
    • In-stock
      2,4-Difluoro-3-iodopyridine|CS-0005569
      837364-88-2

    References

    • Journal of Organic Chemistry, , vol. 70, # 7 p. 2494 - 2502

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.9644
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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