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CS-W001157 4
Total: USD 88.00

4-Cyclopropylthiazol-2-amine

  • CAS No. 324579-90-0

  • Cat. No. CS-0044021
  • Purity≥96%
  • MDL No.MFCD01571854

*For research and further manufacturing use only, not for direct human use.

4-Cyclopropylthiazol-2-amine|CS-0044021

Structure of 324579-90-0

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General Information

  • CAS No. 324579-90-0
  • Cat. No. CS-0044021
  • Purity ≥96%
  • MDL No. MFCD01571854
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂S
  • Molecular Weight 140.21
  • Synonym(s) 4-Cyclopropyl-2-Thiazolamine
  • SMILES NC1=NC(C2CC2)=CS1

Description

4-Cyclopropylthiazol-2-amine features a thiazole core with a cyclopropyl group at the 4-position and an amino substituent at the 2-position, delivering enhanced metabolic stability and tunable basicity. This scaffold integrates readily into kinase inhibitor frameworks and serves as a key building block in medicinal chemistry campaigns targeting purine-binding sites.

Application

4-Cyclopropylthiazol-2-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the synthesis of thiazole-based scaffolds with enhanced metabolic stability. Its cyclopropyl substituent imparts favorable steric and electronic properties, while the amine functionality facilitates straightforward derivatization via amidation, alkylation, or coupling reactions. The compound exhibits good bench stability and is compatible with standard reaction conditions, making it a practical choice for the development of API intermediates and targeted small-molecule libraries.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.6027
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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