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CS-W001157 4
Total: USD 88.00

1-Methyl-1H-indazol-4-amine

  • CAS No. 77894-69-0

  • Cat. No. CS-W019852
  • Purity≥98%
  • MDL No.MFCD09870041

*For research and further manufacturing use only, not for direct human use.

1-Methyl-1H-indazol-4-amine|CS-W019852

Structure of 77894-69-0

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General Information

  • CAS No. 77894-69-0
  • Cat. No. CS-W019852
  • Purity ≥98%
  • MDL No. MFCD09870041
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉N₃
  • Molecular Weight 147.18
  • Synonym(s) 1-Methyl-1H-indazol-4-ylamine
  • SMILES NC1=CC=CC2=C1C=NN2C

Description

1-Methyl-1H-indazol-4-amine features a nitrogen-rich heterocyclic core with enhanced solubility and stability under standard conditions. This scaffold integrates readily into medicinal chemistry campaigns, offering a versatile handle for derivatization at the amine site. The methyl substitution improves metabolic resilience while maintaining favorable electronic properties for target engagement.

Application

1-Methyl-1H-indazol-4-amine serves as a versatile building block in medicinal chemistry, enabling rapid access to indazole-based scaffolds through standard coupling reactions. Its amine functionality facilitates straightforward derivatization, while the methyl group enhances metabolic stability and modulates solubility. The compound exhibits excellent bench stability, ease of purification, and compatibility with diverse functional groups, making it ideal for high-throughput synthesis of kinase inhibitors and other bioactive heterocycles.

Synthesis

  • Route1

    References

    • WO2004/46133 A1, ; Page 28 ; WO 2004/046133 A1
  • Route2

    References

    • WO2010/45401 A1, ; Page/Page column 38 ; WO 2010/045401 A1
  • Route3

    References

    • Heterocycles, , vol. 68, # 12 p. 2595 - 2605

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   1.1555
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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