Lot numbers can be found on the outside label of a product:
(1-Methyl-1H-indazol-6-yl)amine
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CAS No. 74728-65-7
- Cat. No. CS-W023179
- Purity≥98%
- MDL No.MFCD00456076
*For research and further manufacturing use only, not for direct human use.
Structure of 74728-65-7
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General Information
- CAS No. 74728-65-7
- Cat. No. CS-W023179
- Purity ≥98%
- MDL No. MFCD00456076
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₉N₃
- Molecular Weight 147.18
- Synonym(s) 1-methyl-1H-indazol-6-amine
- SMILES NC1=CC=C2C(N(C)N=C2)=C1
Description
(1-Methyl-1H-indazol-6-yl)amine features a planar, electron-rich indazole core with a strategically positioned methylated amine handle. This nitrogen-rich scaffold integrates readily into medicinal chemistry campaigns, offering enhanced solubility and metabolic stability in target-directed synthesis. The para-amino substitution enables direct coupling reactions without protecting groups.
Application
(1-Methyl-1H-indazol-6-yl)amine serves as a versatile building block in medicinal chemistry, enabling efficient access to indazole-based scaffolds through standard coupling reactions. Its moderate basicity and stability under common reaction conditions facilitate functionalization at the amine site, while the electron-rich indazole core supports diverse heterocyclic transformations. The compound functions effectively in amide bond formation, Suzuki-Miyaura couplings, and electrophilic substitution processes, making it valuable for lead optimization campaigns in pharmaceutical R&D.
Synthesis
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Route1
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6850-23-3 - ~97%
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In-stock
74728-65-7
References
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The United States of America, as represented by the Secretary, Department of Health and Human Services; Science Applications International Corporation (SAIC); Albany Molecular Research, Inc. Patent: WO2009/42907 A1, 2009 ; Location in patent: Page/Page column 84-85 ; WO 2009/042907 A1
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Route2
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In-stock
7597-18-4 - ~%
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In-stock
74728-65-7
References
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Heterocycles, , vol. 68, # 12 p. 2595 - 2605
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References
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Heterocycles, , vol. 68, # 12 p. 2595 - 2605
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 43.84
- LogP 1.1555
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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