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CS-W001157 4
Total: USD 88.00

2-Methyl-2H-indazol-5-amine

  • CAS No. 60518-59-4

  • Cat. No. CS-0006086
  • Purity≥98%
  • MDL No.MFCD03787060

*For research and further manufacturing use only, not for direct human use.

2-Methyl-2H-indazol-5-amine|CS-0006086

Structure of 60518-59-4

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General Information

  • CAS No. 60518-59-4
  • Cat. No. CS-0006086
  • Purity ≥98%
  • MDL No. MFCD03787060
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉N₃
  • Molecular Weight 147.18
  • Synonym(s) None
  • SMILES NC1=CC2=CN(C)N=C2C=C1

Description

2-Methyl-2H-indazol-5-amine features a fused bicyclic indazole core with a methyl group at the 2-position and a primary amine at the 5-position. This configuration imparts enhanced solubility and stability under standard bench conditions, enabling straightforward incorporation into medicinal chemistry campaigns. The electron-rich heterocycle serves as a privileged scaffold for targeted ligand design in kinase inhibition and CNS-targeted drug discovery.

Application

2-Methyl-2H-indazol-5-amine serves as a versatile building block for medicinal chemistry and heterocyclic synthesis, enabling efficient access to indazole-based scaffolds. Its amine functionality facilitates direct coupling reactions and derivatization, while the methyl group enhances metabolic stability and modulates electronic properties. The compound exhibits excellent bench stability and compatibility with standard reaction conditions, making it well-suited for multi-step synthetic sequences in API development.

Synthesis

  • Route1

    References

    • Miloudi, Abdellah; El Abed, Douniazed; Boyer, Gerard; Galy, Jean-Pierre Heterocycles, 2006 , vol. 68, # 12 p. 2595 - 2605
  • Route2

    References

    • Heterocycles, , vol. 68, # 12 p. 2595 - 2605

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   1.1555
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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