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CS-W001157 4
Total: USD 88.00

7-Nitroindazole

  • CAS No. 2942-42-9

  • Cat. No. CS-D0829
  • Purity≥95%
  • MDL No.MFCD00022789

*For research and further manufacturing use only, not for direct human use.

7-Nitroindazole|CS-D0829

Structure of 2942-42-9

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General Information

  • CAS No. 2942-42-9
  • Cat. No. CS-D0829
  • Purity ≥95%
  • MDL No. MFCD00022789
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅N₃O₂
  • Molecular Weight 163.14
  • Synonym(s) None
  • SMILES O=[N+](C1=CC=CC2=C1NN=C2)[O-]

Description

Inhibiting neuronal nitric oxide synthase with 7-Nitroindazole (CAS 2942-42-9) achieves a 10-fold selectivity over other NOS isoforms in vitro, disrupting NO-mediated signaling cascades.

Synthesis

  • Route1

    References

    • GRUeNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; SCHIENE, Klaus; DE VRY, Jean; DAMANN, Nils; FRORMANN, Sven; LESCH, Bernhard; LEE, Jeewoo; KIM, Yong-Soo; KIM, Myeong-Seop Patent: WO2010/127855 A1, 2010 ; Location in patent: Page/Page column 124; 125 ;
  • Route2
    • tert-Butyl 7-nitro-1H-indazole-1-carboxylate|CS-0696967
      173459-52-4
    • ~98%
    • In-stock
      7-Nitroindazole|CS-D0829
      2942-42-9

    References

    • El Kazzouli, Said; Koubachi, Jamal; Berteina-Raboin, Sabine; Mouaddib, Abderrahim; Guillaumet, Gerald Tetrahedron Letters, 2006 , vol. 47, # 48 p. 8575 - 8577
  • Route3

    References

    • Lokhande; Raheem, Abdul; Sabale; Chabukswar; Jagdale Tetrahedron Letters, 2007 , vol. 48, # 39 p. 6890 - 6892

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H319-H351-H360
Precautionary Statements : P264-P270-P280-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   71.82
  • LogP   1.4711
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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