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CS-W001157 4
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Dicyclopropylketone

  • CAS No. 1121-37-5

  • Cat. No. CS-0076033
  • Purity≥98%
  • MDL No.MFCD00001276

*For research and further manufacturing use only, not for direct human use.

Dicyclopropylketone|CS-0076033

Structure of 1121-37-5

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General Information

  • CAS No. 1121-37-5
  • Cat. No. CS-0076033
  • Purity ≥98%
  • MDL No. MFCD00001276
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀O
  • Molecular Weight None
  • Synonym(s) Methanone, dicyclopropyl-
  • SMILES O=C(C1CC1)C2CC2

Description

Dicyclopropylketone features a sterically encumbered ketone moiety flanked by two cyclopropyl rings, conferring enhanced stability and unique reactivity in organometallic transformations. This bench-stable carbonyl compound serves as a selective building block in synthetic pathways requiring constrained molecular geometry.

Application

Dicyclopropylketone serves as a versatile building block in organic synthesis, enabling the construction of complex carbocyclic and heterocyclic frameworks. Its cyclopropyl groups provide enhanced steric differentiation and influence regioselectivity in nucleophilic additions. The ketone functionality facilitates enolization and acts as a key handle for reductive amination, aldol reactions, and transition-metal-catalyzed coupling processes. Bench-stable and amenable to purification via distillation or chromatography, it functions reliably in multistep syntheses requiring robust functional group tolerance.

Synthesis

  • Route1

    References

    • Lou, Ji-Dong; Gao, Chun-Ling; Ma, Yi-Chun; Huang, Li-Hong; Li, Li Tetrahedron Letters, 2006 , vol. 47, # 3 p. 311 - 313
  • Route2
    • null|null
      38381-24-7
    • ~99%
    • In-stock
      Dicyclopropylketone|CS-0076033
      1121-37-5

    References

    • Tabuchi, Toshihiko; Nojima, Masatomo; Kusabayashi, Shigekazu Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 12 p. 3043 - 3046
  • Route3
    • null|null
      75-89-8
    • null|null
      83961-10-8
    • ~%
    • null|null
      70106-37-5
    • null|null
      70106-36-4
    • null|null
      97487-37-1
    • In-stock
      Dicyclopropylketone|CS-0076033
      1121-37-5

    References

    • Journal of Organic Chemistry, , vol. 48, # 26 p. 5260 - 5268

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 2924
Class : 3,8
Packing Group : Ⅲ
Hazard Statements : H226-H314-H318
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P370+P378-P403+P235-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   1.3755
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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