Lot numbers can be found on the outside label of a product:
2-(4-Bromophenyl)-2-methylpropanoic acid
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CAS No. 32454-35-6
- Cat. No. CS-M1477
- Purity≥98%
- MDL No.MFCD02684220
*For research and further manufacturing use only, not for direct human use.
Structure of 32454-35-6
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General Information
- CAS No. 32454-35-6
- Cat. No. CS-M1477
- Purity ≥98%
- MDL No. MFCD02684220
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₁₁BrO₂
- Molecular Weight 243.10
- Synonym(s) 2-(4-bromophenyl)-2-methylpropionicacid; 2-(4-Bromophenyl)-2-methylpropanoic acid
- SMILES CC(C)(C(O)=O)C1=CC=C(Br)C=C1
Description
2-(4-Bromophenyl)-2-methylpropanoic acid features a sterically hindered tert-butyl-like core paired with an electron-deficient bromophenyl group, enabling robust coupling in late-stage functionalization. This bench-stable carboxylic acid integrates readily into pharmaceutical scaffolds and serves as a key intermediate for bioactive molecule synthesis under standard conditions.
Application
2-(4-Bromophenyl)-2-methylpropanoic acid serves as a versatile building block for the synthesis of pharmaceutical intermediates and functionalized biaryls. Its robust benzylic carboxylic acid functionality enables direct derivatization via amide, ester, or acyl chloride formation, while the pendant bromine facilitates palladium-catalyzed cross-coupling reactions. The tert-butyl group provides steric protection and enhances bench stability, simplifying purification and handling in multi-step syntheses.
Synthesis
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Route1
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In-stock
154825-97-5 - ~93%
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In-stock
32454-35-6
References
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pfizer Inc Patent: US2010/197591 A1, 2010 ; Location in patent: Page/Page column 16 ; US 20100197591 A1
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Route2
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In-stock
826-55-1 - ~80%
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In-stock
32454-35-6
References
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Divi's Laboratories Limited Patent: EP2532644 A1, 2012 ; Location in patent: Page/Page column 5 ;
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Route3
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In-stock
32454-36-7 - ~%
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In-stock
32454-35-6
References
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US2006/149070 A1, ; Page/Page column 31 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302
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Precautionary Statements : P264-P270-P330-P501
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Quality Control
Computational Chemistry Data
- TPSA 37.3
- LogP 2.8113
- H_Acceptors 1
- H_Donors 1
- Rotatable_Bonds 2
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Key Words
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