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CS-W001157 4
Total: USD 88.00

2-((5-Bromopyrimidin-2-yl)thio)acetic acid

  • CAS No. 52767-92-7

  • Cat. No. CS-0060280
  • Purity≥97%
  • MDL No.MFCD09754081
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-((5-Bromopyrimidin-2-yl)thio)acetic acid|CS-0060280

Structure of 52767-92-7

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Description

This bromopyrimidinethioacetic acid features a pyrimidine core functionalized with a bromine atom and a thioacetic side chain, enabling direct conjugation in cross-coupling reactions. The electron-deficient pyrimidine ring enhances reactivity in nucleophilic substitution processes, while the thioether linkage offers stability under standard conditions. Ideal for constructing bioactive heterocycles and pharmaceutical intermediates.

Application

2-((5-Bromopyrimidin-2-yl)thio)acetic acid serves as a versatile building block for the synthesis of pyrimidine-based heterocycles and bioactive molecules. Its bromine substituent enables facile palladium-catalyzed cross-coupling reactions, while the thioacetic acid moiety offers a handle for further functionalization. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for medicinal chemistry and process development workflows.

General Information

  • CAS No. 52767-92-7
  • Cat. No. CS-0060280
  • Purity ≥97%
  • MDL No. MFCD09754081
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrN₂O₂S
  • Molecular Weight 249.09
  • Synonym(s) OTAVA-BB 1056252
  • SMILES C1=C(C=NC(=N1)SCC(=O)O)Br

Computational Chemistry Data

  • TPSA   63.08
  • LogP   1.4158
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   3

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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