8-Bromoimidazo[1,2-a]pyridine-2-carboxylic acid

Name: 8-Bromoimidazo[1,2-a]pyridine-2-carboxylic acid
Brand: ChemScene
Availability: InStock
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CAS No. 1026201-45-5
Cat. No. CS-W000732
Purity≥95%
MDL No.MFCD12195903

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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8-Bromoimidazo[1,2-a]pyridine-2-carboxylic acid|CS-W000732

Structure of 1026201-45-5

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General Information

CAS No. 1026201-45-5
Cat. No. CS-W000732
Purity ≥95%
MDL No. MFCD12195903
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₅BrN₂O₂
Molecular Weight 241.04
Synonym(s) 8-BroMoH-iMidazo[1,2-a]pyridine-2-carboxylic acid
SMILES OC(=O)c1cn2cccc(Br)c2n1

Description

8-Bromoimidazo[1,2-a]pyridine-2-carboxylic acid features a brominated imidazopyridine core with a carboxylic acid handle, enabling direct conjugation in medicinal chemistry. This scaffold combines electronic modulation via the bromo substituent with synthetic versatility through the carboxylic acid group, supporting efficient derivatization in drug discovery and materials synthesis under standard conditions.

Application

8-Bromoimidazo[1,2-a]pyridine-2-carboxylic acid serves as a versatile building block for constructing biologically relevant heterocyclic scaffolds. Its bromo group enables palladium-catalyzed cross-coupling reactions, while the carboxylic acid facilitates amide bond formation and derivatization. The molecule exhibits bench stability and compatibility with standard purification methods, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

Synthesis

Route1
- In-stock
  
  1038393-19-9
- ~88%
- In-stock
  
  1026201-45-5
References
- ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC; GIJSEN, Henricus, Jacobus, Maria; MACDONALD, Gregor, James; BISCHOFF, Francois, Paul; TRESADERN, Gary, John; TRABANCO-SUAREZ, Andres, Avelino; VAN BRANDT, Sven, Franciscus, Anna; BERTHELOT, Didier, Jean-Claude Patent: WO2010/70008 A1, 2010 ; Location in patent: Page/Page column 58 ; WO 2010/070008 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 54.6
LogP 1.795
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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8-Bromoimidazo[1,2-a]pyridine-2-carboxylic acid

CAS No. 1026201-45-5

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