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CS-W001157 4
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((2S,7aS)-2-Fluorohexahydro-1H-pyrrolizin-7a-yl)methanol

  • CAS No. 2820537-15-1

  • Cat. No. CS-0613533
  • Molecule weight159.20
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

((2S,7aS)-2-Fluorohexahydro-1H-pyrrolizin-7a-yl)methanol|CS-0613533

Structure of 2820537-15-1

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General Information

  • CAS No. 2820537-15-1
  • Cat. No. CS-0613533
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₄FNO
  • Molecular Weight 159.20
  • Synonym(s) None
  • SMILES OC[C@@]12CCCN1C[C@@H](F)C2

Description

This fluorinated pyrrolizidine derivative features a stereodefined hydroxymethyl group at the 7a-position, delivering enhanced metabolic stability and improved solubility in polar solvents. The (2S,7aS) configuration ensures precise spatial orientation for targeted interactions in synthetic intermediates. This scaffold integrates readily into bioactive molecule frameworks where controlled polarity and conformational rigidity are critical.

Application

((2S,7aS)-2-Fluorohexahydro-1H-pyrrolizin-7a-yl)methanol serves as a stereochemically defined building block for fluorinated nitrogen heterocycles. Its bench-stable, chiral pyrrolizidine core enables selective functionalization and acts as a versatile scaffold in medicinal chemistry synthesis. The hydroxymethyl group facilitates derivatization via standard coupling reactions, while the fluorine substituent enhances metabolic stability and modulates electronic properties—key attributes for optimizing pharmacophores in target-directed compound libraries.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   23.47
  • LogP   0.5551
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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