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Structure of 2621939-48-6
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This fluorinated tetrahydro-1H-pyrrolizine scaffold features a chiral alcohol handle at the 7a-position, enabling direct functionalization in synthetic routes. The (2S,7aR) stereochemistry ensures high diastereoselectivity in downstream transformations, while the fluorine atom enhances metabolic stability and modulates electronic properties. This bench-stable building block integrates efficiently into bioactive molecule architectures requiring constrained, polar, and electron-deficient motifs.
((2S,7aR)-2-Fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol serves as a valuable chiral building block in medicinal chemistry, enabling the construction of fluorinated heterocyclic scaffolds relevant to bioactive molecule design. Its stable tetrahydro-1H-pyrrolizine core exhibits favorable functional group tolerance and facilitates downstream transformations such as coupling reactions and derivatization. The pendant hydroxymethyl group offers a versatile handle for further functionalization, while the stereochemistry at C2 and C7a ensures predictable reactivity in asymmetric synthesis. This compound is bench-stable and amenable to purification, supporting its use in iterative synthetic sequences and scale-up processes.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: