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Structure of 2454490-66-3
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This fluorinated tetrahydro-1H-pyrrolizine scaffold features a chiral methanol handle at the 2-position, enabling direct functionalization in asymmetric synthesis. The constrained bicyclic core exhibits enhanced metabolic stability and rigidity, ideal for medicinal chemistry applications requiring precise stereocontrol and improved pharmacokinetic profiles.
((2R,7aR)-2-Fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol serves as a valuable chiral building block for the synthesis of fluorinated heterocyclic scaffolds. Its well-defined stereochemistry and pendant hydroxymethyl group enable selective functionalization and coupling reactions. The molecule exhibits good bench stability and facilitates incorporation into complex molecular architectures via standard transformations, including derivatization to esters, ethers, or amides.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: