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2-Methyl-2-(methylamino)propan-1-ol

  • CAS No. 27646-80-6

  • Cat. No. CS-W018699
  • Purity≥95%
  • MDL No.MFCD12184529

*For research and further manufacturing use only, not for direct human use.

2-Methyl-2-(methylamino)propan-1-ol|CS-W018699

Structure of 27646-80-6

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General Information

  • CAS No. 27646-80-6
  • Cat. No. CS-W018699
  • Purity ≥95%
  • MDL No. MFCD12184529
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₃NO
  • Molecular Weight 103.17
  • Synonym(s) NSC 147612
  • SMILES CC(NC)(C)CO

Description

2-Methyl-2-(methylamino)propan-1-ol is a tertiary amine alcohol featuring a sterically hindered central carbon and a pendant methylamino group. This structure imparts enhanced stability and solubility in polar solvents, enabling efficient use in synthesis of pharmaceutical intermediates and chiral ligands under standard conditions.

Application

2-Methyl-2-(methylamino)propan-1-ol serves as a versatile bifunctional building block in synthetic organic chemistry, combining a tertiary amine with a primary alcohol for use in ligand development, protecting group strategies, and the construction of heterocyclic scaffolds. Its bench-stable nature and tolerance to diverse reaction conditions facilitate efficient functionalization in multi-step syntheses.

Synthesis

  • Route1

    References

    • BIOCOPEA LIMITED; BANNISTER, Robin Mark Patent: WO2010/103312 A1, 2010 ; Location in patent: Page/Page column 10 ;
  • Route2
    • Ethyl 2-methyl-2-(methylamino)propanoate|CS-0260653
      58743-30-9
    • ~%
    • In-stock
      2-Methyl-2-(methylamino)propan-1-ol|CS-W018699
      27646-80-6

    References

    • Kuznetsov,S.G.; El'tsov,A.V. J. Gen. Chem. USSR (Engl. Transl.), 1962 , vol. 32, p. 511 - 515,502 - 506

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   32.26
  • LogP   -0.0233
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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