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HDGFRP2/PSIP1-IN-1

  • CAS No. 166196-54-9

  • Cat. No. CS-0060267
  • Molecule weight224.06
  • Purity≥95%
  • MDL No.MFCD14657915

*For research and further manufacturing use only, not for direct human use.

HDGFRP2/PSIP1-IN-1|CS-0060267

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General Information

  • CAS No. 166196-54-9
  • Cat. No. CS-0060267
  • Purity ≥95%
  • MDL No. MFCD14657915
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆BrN₃
  • Molecular Weight 224.06
  • Synonym(s) 4-(4-Bromo-1H-pyrazol-5-yl)pyridine
  • SMILES BrC1=CNN=C1C2=CC=NC=C2

Description

HDGFRP2/PSIP1-IN-1 is a potent, selective inhibitor targeting the HDGFRP2/PSIP1 protein-protein interaction interface. This compound disrupts critical regulatory complexes involved in transcriptional control and chromatin remodeling. Designed for high target engagement under physiological conditions, it offers a robust tool for probing epigenetic signaling pathways in cellular models.

Application

HDGFRP2/PSIP1-IN-1 serves as a well-characterized small-molecule inhibitor targeting the HDGFRP2/PSIP1 protein interaction interface, enabling selective disruption of associated transcriptional complexes. This compound exhibits robust biochemical stability and facilitates target engagement in cellular assays, supporting its utility in probing epigenetic regulatory pathways. Its defined structure and consistent performance make it a reliable tool for functional validation in medicinal chemistry and systems biology workflows.

Synthesis

  • Route1

    References

    • Hansen, Joshua D.; Grina, Jonas; Newhouse, Brad; Welch, Mike; Topalov, George; Littman, Nicole; Callejo, Michele; Gloor, Susan; Martinson, Matthew; Laird, Ellen; Brandhuber, Barbara J.; Vigers, Guy; Morales, Tony; Woessner, Rich; Randolph, Nikole; Lyssikatos, Joseph; Olivero, Alan Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 16 p. 4692 - 4695

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   2.2342
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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