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CS-W001157 4
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(3,4-Difluoro-2-methoxyphenyl)boronic acid

  • CAS No. 905583-06-4

  • Cat. No. CS-0095018
  • Purity≥96%
  • MDL No.MFCD13181640

*For research and further manufacturing use only, not for direct human use.

(3,4-Difluoro-2-methoxyphenyl)boronic acid|CS-0095018

Structure of 905583-06-4

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General Information

  • CAS No. 905583-06-4
  • Cat. No. CS-0095018
  • Purity ≥96%
  • MDL No. MFCD13181640
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BF₂O₃
  • Molecular Weight 187.94
  • Synonym(s) 3,4-Difluoro-2-methoxyphenylboronic acid
  • SMILES OB(C1=CC=C(F)C(F)=C1OC)O

Description

This boronic acid features a trifluorinated aryl core with a methoxy substituent at the ortho position, delivering enhanced stability and solubility in polar organic solvents. The electron-deficient ring facilitates efficient Suzuki-Miyaura coupling under mild conditions, enabling rapid assembly of complex heterocycles and biaryl architectures in medicinal chemistry workflows.

Application

(3,4-Difluoro-2-methoxyphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds. Its fluorinated aryl core enhances metabolic stability and modulates electronic properties, while the methoxy group provides ortho-directing capability and improved solubility. The boronic acid functionality offers excellent bench stability and compatibility with diverse reaction conditions, facilitating straightforward purification and broad functional group tolerance.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   -0.3468
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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