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CS-W001157 4
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1-Amino-1-cyclohexanecarboxylic acid

  • CAS No. 2756-85-6

  • Cat. No. CS-W016418
  • Purity≥97%
  • MDL No.MFCD00001487

*For research and further manufacturing use only, not for direct human use.

1-Amino-1-cyclohexanecarboxylic acid|CS-W016418

Structure of 2756-85-6

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General Information

  • CAS No. 2756-85-6
  • Cat. No. CS-W016418
  • Purity ≥97%
  • MDL No. MFCD00001487
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₃NO₂
  • Molecular Weight 143.18
  • Synonym(s) 1-Amino-cyclohexanecarboxylic acid
  • SMILES O=C(C1(N)CCCCC1)O

Description

1-Amino-1-cyclohexanecarboxylic acid features a rigid cyclohexane scaffold bearing both amino and carboxylic acid functionalities, enabling its use in peptide mimetics and chiral building blocks. The adjacent polar groups enhance solubility and facilitate conjugation reactions under standard conditions.

Application

1-Amino-1-cyclohexanecarboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of cyclohexane-based bioactive molecules. Its dual functional groups—amine and carboxylic acid—facilitate straightforward peptide coupling and derivatization, while the rigid cyclohexane scaffold provides conformational stability. The compound exhibits good bench stability and compatibility with standard purification techniques, making it well-suited for use in iterative synthetic workflows and API intermediate development.

Synthesis

  • Route1
    • 1,3-Diazaspiro[4.5]decane-2,4-dione|CS-0084878
      702-62-5
    • ~73%
    • In-stock
      1-Amino-1-cyclohexanecarboxylic acid|CS-W016418
      2756-85-6

    References

    • Stoyanov, Neyko; Marinov, Marin Acta Chimica Slovenica, 2012 , vol. 59, # 3 p. 680 - 685,6 Title/Abstract Full Text Show Details Stoyanov, Neyko; Marinov, Marin Acta Chimica Slovenica, 2012 , vol. 59, # 3 p. 680 - 685
  • Route2
    • null|null
      610-10-6
    • ~%
    • In-stock
      1-Amino-1-cyclohexanecarboxylic acid|CS-W016418
      2756-85-6
    • rel-(1R,2R)-2-Aminocyclohexane-1-carboxylic acid|CS-0130605
      5691-19-0

    References

    • Kidani; Yoshinori Patent: US4255347 A1, 1981 ;
  • Route3

    References

    • Wang, Boyuan; Zhang, Wei; Zhang, Leilei; Du, Da-Ming; Liu, Gang; Xu, Jiaxi European Journal of Organic Chemistry, 2008 , # 2 p. 350 - 355

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.32
  • LogP   0.7326
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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