Lot numbers can be found on the outside label of a product:
Fmoc-Ac6c-OH
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CAS No. 162648-54-6
- Cat. No. CS-0044443
- Purity≥97%
- MDL No.MFCD00273464
*For research and further manufacturing use only, not for direct human use.
Structure of 162648-54-6
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General Information
- CAS No. 162648-54-6
- Cat. No. CS-0044443
- Purity ≥97%
- MDL No. MFCD00273464
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₂₂H₂₃NO₄
- Molecular Weight 365.42
- Synonym(s) 1-(Fmoc-amino)cyclohexanecarboxylic acid
- SMILES O=C(C1(NC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O)CCCCC1)O
Description
Fmoc-Ac6c-OH is a protected lysine derivative featuring a six-carbon aliphatic side chain, enabling efficient incorporation into peptide sequences. The Fmoc group ensures orthogonal protection, while the acetyl moiety enhances solubility and stability under standard coupling conditions. This reagent streamlines the synthesis of modified peptides with tailored side-chain functionality.
Application
Fmoc-Ac6c-OH serves as a versatile building block for solid-phase peptide synthesis, enabling the incorporation of a C-terminal acetylated 6-aminocaproic acid side chain. Its stability under standard Fmoc-deprotection conditions and compatibility with diverse coupling protocols facilitate efficient conjugation workflows. The protected amine and carboxylic acid groups allow orthogonal functionalization, supporting modular assembly of peptidomimetics and macrocyclic scaffolds.
Synthesis
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Route1
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28920-43-6 -
39692-17-6 - ~65%
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In-stock
162648-54-6
References
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Lescrinier, Theo; Hendrix, Chris; Kerremans, Luc; Rozenski, Jef; Link, Andreas; Samyn, Bart; Van Aerschot, Arthur; Lescrinier, Eveline; Eritja, Ramon; Van Beeumen, Jozef; Herdewijn, Piet Chemistry - A European Journal, 1998 , vol. 4, # 3 p. 425 - 433
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References
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American Home Products Corporation Patent: US5385910 A1, 1995 ;
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Route3
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28920-43-6
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In-stock
2756-85-6 - ~71%
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In-stock
162648-54-6
References
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Babu, Vommina V. Suresh; Ananda, Kuppanna Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2001 , vol. 40, # 1 p. 70 - 74
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 75.63
- LogP 4.3126
- H_Acceptors 3
- H_Donors 2
- Rotatable_Bonds 4
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Key Words
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