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CS-W001157 4
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Methyl 1-aminocyclohexanecarboxylate hydrochloride

  • CAS No. 37993-32-1

  • Cat. No. CS-D0550
  • Purity≥97%
  • MDL No.MFCD09264353

*For research and further manufacturing use only, not for direct human use.

Methyl 1-aminocyclohexanecarboxylate hydrochloride|CS-D0550

Structure of 37993-32-1

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General Information

  • CAS No. 37993-32-1
  • Cat. No. CS-D0550
  • Purity ≥97%
  • MDL No. MFCD09264353
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₆ClNO₂
  • Molecular Weight 193.67
  • Synonym(s) Methyl 1-aminocyclohexanecarboxylate HYDROCHLORIDE Salt
  • SMILES COC(C1(CCCCC1)N)=O.Cl

Description

Methyl 1-aminocyclohexanecarboxylate hydrochloride offers a bench-stable, moisture-tolerant platform for synthesizing bioactive cyclohexane derivatives. The protonated amine enhances solubility in polar solvents while preserving reactivity for downstream functionalization. This salt form facilitates handling and purification in synthetic workflows involving nitrogen-containing heterocycles or pharmaceutical intermediates.

Application

Methyl 1-aminocyclohexanecarboxylate hydrochloride serves as a versatile building block for cyclohexane-based scaffolds in medicinal chemistry. The protected amine and ester functionalities enable sequential transformations, including reduction, amidation, and cyclization reactions. Its bench-stable crystalline form facilitates handling and purification, while the hydrochloride salt enhances solubility in polar solvents, supporting efficient coupling and functionalization in standard synthetic workflows.

Synthesis

  • Route1
    • null|null
      67-56-1
    • In-stock
      1-Amino-1-cyclohexanecarboxylic acid|CS-W016418
      2756-85-6
    • ~91%
    • In-stock
      Methyl 1-aminocyclohexanecarboxylate hydrochloride|CS-D0550
      37993-32-1

    References

    • Kantharaju; Babu, Vommina V. Suresh Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006 , vol. 45, # 8 p. 1942 - 1944
  • Route2
    • In-stock
      1-Amino-1-cyclohexanecarboxylic acid|CS-W016418
      2756-85-6
    • null|null
      75-36-5
    • ~99%
    • In-stock
      Methyl 1-aminocyclohexanecarboxylate hydrochloride|CS-D0550
      37993-32-1

    References

    • Maegawa, Tomohiro; Otake, Kazuki; Hirosawa, Keiichi; Goto, Akihiro; Fujioka, Hiromichi Organic Letters, 2012 , vol. 14, # 18 p. 4798 - 4801
  • Route3

    References

    • Takeda Chemical Industries, Inc. Patent: US6407116 B1, 2002 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   1.2428
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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