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Structure of 273-21-2
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1H-Imidazo[4,5-b]pyridine is a rigid, electron-rich heterocycle featuring a fused imidazole-pyridine core. This scaffold exhibits strong π-conjugation and planarity, enabling effective integration into advanced materials and pharmaceutical scaffolds. The nitrogen-rich framework enhances solubility in polar solvents and supports metal coordination. Its bench-stable nature facilitates handling under standard laboratory conditions.
1H-Imidazo[4,5-b]pyridine serves as a versatile heterocyclic scaffold in medicinal chemistry, enabling efficient access to biologically active compounds through established functionalization at the 2-, 4-, and 5-positions. Its inherent stability and compatibility with standard coupling reactions facilitate rapid diversification, while its planar structure supports favorable π–π interactions in target binding. This core functions effectively in parallel synthesis campaigns and scale-up processes, offering robust performance in amide bond formation, Suzuki-Miyaura coupling, and electrophilic substitution.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302
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Precautionary Statements : P264-P270-P330-P501
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Lot numbers can be found on the outside label of a product: