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CS-W001157 4
Total: USD 88.00

5-methyl-3H-imidazo[4,5-b]pyridine

  • CAS No. 27582-24-7

  • Cat. No. CS-0059057
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-methyl-3H-imidazo[4,5-b]pyridine|CS-0059057

Structure of 27582-24-7

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Description

5-Methyl-3H-imidazo[4,5-b]pyridine serves as a privileged heterocyclic scaffold in medicinal chemistry, featuring a fused imidazole-pyridine core with a methyl substituent at the 5-position. This electron-rich system enhances metabolic stability and facilitates π–π stacking interactions in target binding pockets. The compound demonstrates excellent bench stability and solubility in common organic solvents, enabling straightforward integration into multi-step synthetic sequences for drug discovery campaigns.

Application

5-Methyl-3H-imidazo[4,5-b]pyridine serves as a versatile heterocyclic building block in medicinal chemistry, offering a rigid, planar scaffold with defined nitrogen positioning. It functions as a key core for kinase inhibitors and CNS-targeted therapeutics, enabling efficient derivatization via electrophilic substitution or transition-metal-catalyzed coupling. The methyl group provides a handle for selective functionalization, while the imidazopyridine framework exhibits favorable metabolic stability and moderate lipophilicity. Its bench-stable nature and compatibility with standard purification methods make it suitable for high-throughput synthesis and lead optimization campaigns.

General Information

  • CAS No. 27582-24-7
  • Cat. No. CS-0059057
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇N₃
  • Molecular Weight 133.15
  • Synonym(s) 5-methyl-1H-imidazo[4,5-b]pyridine
  • SMILES CC1=CC=C2C(NC=N2)=N1

Computational Chemistry Data

  • TPSA   41.57
  • LogP   1.26632
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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