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CS-W001157 4
Total: USD 88.00

2-Methyl-3H-imidazo[4,5-b]pyridine

  • CAS No. 68175-07-5

  • Cat. No. CS-0081070
  • Purity≥98%
  • MDL No.MFCD03673741

*For research and further manufacturing use only, not for direct human use.

2-Methyl-3H-imidazo[4,5-b]pyridine|CS-0081070

Structure of 68175-07-5

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General Information

  • CAS No. 68175-07-5
  • Cat. No. CS-0081070
  • Purity ≥98%
  • MDL No. MFCD03673741
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇N₃
  • Molecular Weight 133.15
  • Synonym(s) 1H-Imidazo[4,5-b]pyridine, 2-methyl-
  • SMILES CC(N1)=NC2=C1N=CC=C2

Description

2-Methyl-3H-imidazo[4,5-b]pyridine is a heteroaromatic scaffold featuring a fused imidazo-pyridine core with a methyl substituent at the 2-position. This electron-rich system offers enhanced stability and solubility in organic media, enabling straightforward incorporation into medicinal chemistry campaigns. The scaffold serves as a key pharmacophore in kinase inhibitor design and bioactive molecule development.

Application

2-Methyl-3H-imidazo[4,5-b]pyridine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of bioactive scaffolds through functionalization at the 2-methyl and imidazo ring positions. Its stability under standard reaction conditions and compatibility with common coupling protocols facilitate efficient synthesis of complex nitrogen-containing architectures relevant to drug discovery programs.

Synthesis

  • Route1
    • In-stock
      Pyridine, 2,3-diamino-|CS-D1498
      452-58-4
    • null|null
      64-19-7
    • ~56%
    • In-stock
      2-Methyl-3H-imidazo[4,5-b]pyridine|CS-0081070
      68175-07-5

    References

    • MASSACHUSETTS INSTITUTE OF TECHNOLOGY; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; GENZYME CORPORATION Patent: WO2009/137081 A2, 2009 ; Location in patent: Page/Page column 39-40 ; WO 2009/137081 A2
  • Route2
    • In-stock
      Pyridine, 2,3-diamino-|CS-D1498
      452-58-4
    • null|null
      78-39-7
    • ~86%
    • In-stock
      2-Methyl-3H-imidazo[4,5-b]pyridine|CS-0081070
      68175-07-5

    References

    • Patil, Abasaheb V.; Bandgar, Babasaheb P.; Lee, Soo-Hyoung Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 6 p. 1719 - 1722
  • Route3
    • N-(3-Aminopyridin-2-yl)acetamide|CS-0233281
      99314-99-5
    • ~%
    • In-stock
      2-Methyl-3H-imidazo[4,5-b]pyridine|CS-0081070
      68175-07-5

    References

    • Tetrahedron Letters, , vol. 50, # 27 p. 3798 - 3800

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   1.26632
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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