Dimethyl D-glutamate hydrochloride

Name: Dimethyl D-glutamate hydrochloride
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CAS No. 27025-25-8
Cat. No. CS-0021386
Molecule weight211.64
Purity≥97%
MDL No.MFCD00235872

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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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Dimethyl D-glutamate hydrochloride|CS-0021386

Structure of 27025-25-8

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General Information

CAS No. 27025-25-8
Cat. No. CS-0021386
Purity ≥97%
MDL No. MFCD00235872
Storage 4°C, stored under nitrogen, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₄ClNO₄
Molecular Weight 211.64
Synonym(s) (R)-Dimethyl 2-aminopentanedioate (hydrochloride)
SMILES N[C@@H](C(OC)=O)CCC(OC)=O.Cl

Description

Dimethyl D-glutamate hydrochloride features a stable, bench-ready form with enhanced solubility in aqueous and polar organic solvents. This derivative bears two methyl ester groups at the α- and γ-carbons of the D-glutamate backbone, offering defined stereochemistry for use in peptide synthesis and chiral building block applications.

Application

Dimethyl D-glutamate hydrochloride serves as a stable, bench-ready building block for the synthesis of D-amino acid derivatives and peptidomimetics. Its methyl ester functionality enables straightforward deprotection and coupling reactions, while the hydrochloride salt enhances solubility and handling. This compound facilitates efficient access to chiral D-glutamate scaffolds in medicinal chemistry and peptide-based drug discovery workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 78.62
LogP -0.1383
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 4

Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Glutamic acid and derivatives

Life Science Amino Acids and their Derivatives C-protected amino acid

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Amino Acid Derivatives

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids C-ProtectedAmino Acids

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Dimethyl D-glutamate hydrochloride

CAS No. 27025-25-8

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