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CS-W001157 4
Total: USD 88.00

4-Chloro-1H-pyrazole

  • CAS No. 15878-00-9

  • Cat. No. CS-W002459
  • Purity≥98%
  • MDL No.MFCD00159634

*For research and further manufacturing use only, not for direct human use.

4-Chloro-1H-pyrazole|CS-W002459

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General Information

  • CAS No. 15878-00-9
  • Cat. No. CS-W002459
  • Purity ≥98%
  • MDL No. MFCD00159634
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₃ClN₂
  • Molecular Weight 102.52
  • Synonym(s) VITAS-BB TBB000653
  • SMILES Clc1c[nH]nc1

Description

4-Chloro-1H-pyrazole is a bench-stable heterocyclic building block featuring a chlorine atom at the 4-position of the pyrazole ring. This electron-deficient scaffold enables direct functionalization in cross-coupling and electrophilic substitution reactions, offering efficient access to bioactive analogs in medicinal chemistry and agrochemical development.

Application

4-Chloro-1H-pyrazole serves as a versatile heterocyclic building block in medicinal chemistry and synthetic organic chemistry. Its electrophilic chlorine substituent enables facile nucleophilic substitution, enabling the construction of diverse pyrazole derivatives. The compound exhibits good bench stability and compatibility with common reaction conditions, facilitating efficient functionalization for API development and combinatorial library synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H317-H319
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   1.0631
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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