(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(3,4-difluorophenyl)butanoic acid

Name: (S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(3,4-difluorophenyl)butanoic acid
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CAS No. 270063-55-3
Cat. No. CS-W014452
Molecule weight437.44
Purity≥98%
MDL No.MFCD01861051

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(3,4-difluorophenyl)butanoic acid|CS-W014452

Structure of 270063-55-3

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General Information

CAS No. 270063-55-3
Cat. No. CS-W014452
Purity ≥98%
MDL No. MFCD01861051
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₅H₂₁F₂NO₄
Molecular Weight 437.44
Synonym(s) Fmoc-(S)-3-Amino-4-(3,4-difluoro-phenyl)-butyric acid
SMILES O=C(C[C@H](CC1=CC=C(C(F)=C1)F)NC(OCC2C3=C(C=CC=C3)C4=C2C=CC=C4)=O)O

Description

(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(3,4-difluorophenyl)butanoic acid is a chiral building block featuring a fluorenylmethyl carbamate (Fmoc) protecting group and a sterically defined 3,4-difluorophenyl side chain. This configuration enables direct incorporation into peptide synthesis workflows, where the Fmoc moiety ensures orthogonal deprotection under mild basic conditions. The electron-deficient aryl substituent enhances stability during coupling steps and supports efficient solid-phase assembly of bioactive peptides.

Application

(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(3,4-difluorophenyl)butanoic acid serves as a key chiral building block for peptide synthesis and medicinal chemistry campaigns. The Fmoc group enables orthogonal protection and facile deprotection under mild basic conditions, while the (S)-configured α-amino acid scaffold supports efficient coupling reactions. Its 3,4-difluorophenyl moiety enhances metabolic stability and modulates lipophilicity, making it well-suited for constructing bioactive peptidomimetics and API intermediates.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 75.63
LogP 4.8893
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 7

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Phenylalanine and derivatives

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Key Words

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(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(3,4-difluorophenyl)butanoic acid

CAS No. 270063-55-3

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