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CS-W001157 4
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Fmoc-S-3-amino-4,4-diphenyl-butyric acid

  • CAS No. 332062-08-5

  • Cat. No. CS-0182725
  • Purity≥98%
  • MDL No.MFCD02094566

*For research and further manufacturing use only, not for direct human use.

Fmoc-S-3-amino-4,4-diphenyl-butyric acid|CS-0182725

Structure of 332062-08-5

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General Information

  • CAS No. 332062-08-5
  • Cat. No. CS-0182725
  • Purity ≥98%
  • MDL No. MFCD02094566
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₁H₂₇NO₄
  • Molecular Weight 477.55
  • Synonym(s) None
  • SMILES O=C(OCC1C2=CC=CC=C2C3=CC=CC=C13)N[C@@H](CC(O)=O)C(C4=CC=CC=C4)C5=CC=CC=C5

Description

Fmoc-S-3-amino-4,4-diphenyl-butyric acid delivers a sterically hindered, electron-rich amino acid scaffold for peptide synthesis. The Fmoc group enables efficient N-terminal protection, while the diphenyl-substituted aliphatic side chain provides enhanced rigidity and hydrophobic character. This derivative facilitates incorporation of non-natural residues into bioactive peptides, supporting structural studies and stability optimization in therapeutic development.

Application

Fmoc-S-3-amino-4,4-diphenyl-butyric acid serves as a versatile building block for peptide synthesis, enabling the incorporation of a rigid, sterically hindered amino acid with enhanced metabolic stability. The Fmoc group ensures efficient orthogonal protection, while the diphenyl-substituted aliphatic side chain provides unique conformational constraint. This residue facilitates the construction of bioactive peptides and complex heterocyclic scaffolds, offering excellent bench stability, straightforward purification, and compatibility with standard coupling protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   6.2005
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   8

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